Avène Cleanance Comedomed+ intensive anti-blemish care 30ml
Upolife Editorial Team·
By Upolife Editorial Team. Reviewed October 23, 2026.
What Cleanance Comedomed+ is
Avène Cleanance Comedomed+ Intensive Anti-Blemish Care 30ml is a targeted blemish-care concentrate developed by Pierre Fabre within the Avène Cleanance range. According to the manufacturer, it is an intensive anti-blemish treatment (soin intensif anti-imperfections) that acts early on the pathophysiology of acne by targeting the "comedo-switch" — the tipping point in sebaceous stem-cell differentiation.
The 30 ml format is a gel-cream texture with a non-greasy finish. Pierre Fabre states it is suitable from age 9 and for adults.
Key actives: what the manufacturer says
25% Comedoclastin
Comedoclastin is a patented active ingredient derived from milk thistle (Silybum marianum). According to Pierre Fabre, it modulates expression of the K75 protein and inhibits micro-comedone formation. The manufacturer describes it as the first technology with patented properties that acts at the root of blemishes, at the micro-comedone stage.
4% Niacinamide
The manufacturer attributes the following roles to the 4% niacinamide concentration in this formula:
- Acts on persistent post-acne marks
- Reduces sebum production
- Improves the appearance of pores
- Hydrates by stimulating ceramide production
- Reinforces anti-mark and anti-inflammatory action
For more background on ceramides and the skin barrier, see ceramides and skin barrier function.
Texture and finish
Pierre Fabre describes the texture as a gel-cream that is lightweight, non-greasy, and rapidly absorbed, providing comfortable hydration without weighing the skin down. The manufacturer positions it for comfortable morning and evening use.
How to use it: manufacturer directions
According to Pierre Fabre, the correct application method is:
- Cleanse skin first with a Cleanance hygiene product.
- Apply Comedomed+ morning and evening to the cleansed face.
- Use alone or in combination with a prescribed anti-acne medication.
Important: The manufacturer states this product can be used alongside a medicinal anti-acne treatment. It does not replace a prescribed treatment. If you are under medical supervision for acne, consult your healthcare professional before adding or changing products in your routine.
Who it is intended for
Pierre Fabre states the product is suitable from age 9 and for adults with oily, blemish-prone skin. Follow the directions on your own packaging and ask a healthcare professional about persistent or severe acne.
Cleanance Comedomed+ versus the SPF30 fluid: how they differ
The Cleanance range includes a second product that shares the Comedomed+ name: the Fluide Intensif Anti-Imperfections SPF30. According to Avène, these are distinct formulations with different intended uses:
| Feature | Comedomed+ 30ml gel-cream | Fluide Intensif SPF30 |
|---|---|---|
| Primary purpose | Intensive anti-blemish care, morning and evening | Anti-blemish care with daily UV protection |
| UV protection | None stated | SPF30 |
| Intended context | Standalone treatment or alongside prescribed therapy | Developed for acne-prone skin exposed daily to the sun |
| Format | Gel-cream, 30ml | Fluid |
The manufacturer describes the SPF30 fluid as combining Comedomed+ expertise with targeted anti-mark efficacy and a reinforced UV protection formula. The 30ml gel-cream reviewed here does not carry an SPF rating and is the version intended for both morning and evening use as a core treatment step.
Frequently asked questions
What is Comedoclastin and where does it come from?
According to Pierre Fabre, Comedoclastin is a patented active ingredient derived from milk thistle (Silybum marianum). The manufacturer states it modulates expression of the K75 protein and inhibits micro-comedone formation, acting at what they describe as the "comedo-switch" in sebaceous stem-cell differentiation.
How often should Cleanance Comedomed+ 30ml be applied?
The manufacturer (Pierre Fabre) directs morning and evening application on skin that has been cleansed beforehand with a Cleanance hygiene product.
Can Cleanance Comedomed+ be used with a prescribed acne treatment?
Yes. Pierre Fabre states the product can be used alone or in combination with a medicinal anti-acne treatment. It does not replace a prescribed therapy. Consult your healthcare professional if you are under medical supervision for acne.
What is the minimum age for using Cleanance Comedomed+ 30ml?
Pierre Fabre states the product is suitable from age 9 and for adults.
What is the difference between Cleanance Comedomed+ 30ml and the Cleanance SPF30 fluid?
According to Avène, the 30ml gel-cream is an intensive anti-blemish treatment for morning and evening use, with no UV protection. The SPF30 fluid is a separate product developed specifically for acne-prone skin exposed daily to the sun, combining the Comedomed+ approach with SPF30 UV protection. They are not interchangeable.
Sources
- Pierre Fabre: Cleanance Comedomed+ intensive care 30ml
- Avène: Comedomed+ range and distinction from SPF30 fluid
For general information only; not medical advice. Follow the manufacturer’s directions and warnings for the exact product. Read our editorial policy.
